Job Title: Sr. Staff Scientist Bioinformatics

Requisition ID: 137923BR

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $25 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them. Our global team of more than 75,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit www.thermofisher.com.

Location/Division

• Carlsbad, CA
• Biosciences Division

How will you make an impact?

As a Sr Staff Scientist you will leading bioinformatics support of the new technology development within a multidisciplinary team of scientists focused on a single cell research.

What will you do?

• Directly interact with senior R&D leadership, software, engineers, product and project management to develop and execute project plans that support product development initiatives towards analysis of the transcriptome at the single cell level.
• Developing molecular tagging and barcoding designs to uniquely identify thousands of samples
• Designing oligos and primers to implement these designs in RT, amplification, barcoding reactions with whole transcriptomes
• Analyzing and troubleshooting NGS data, hidden biases, read structures to support experimental optimization and development of advanced molecular tagging and to provide constructive feedback to the bench scientists Developing new and customized NGS single cell analysis tools for internal R&D use and as part of customer-facing production software
• Proactively communicating across functions, especially with cell and molecular biologists to interpret sequence results, propose additional experiments, dynamically adjust designs to support the fast-paced development work
• Contributing to the development of customer-facing software, algorithms, visualization

How will you get here?
Education

• PH.D and post doctorate or Master’s degree in AND 7+ years experience in Cell, Molecular, Immunology, Oncology or related science discipline.

Experience

• 5+ years of experience in bioinformatics or a related field
• 2+ years of experience with next generation sequencing data analysis
• 1+ years of experience with single cell sequencing or other single cell techniques

Knowledge, Skills, Job Abilities

• Familiar with next-generation sequencing analysis with a good understanding of software engineering and data analysis principles
• Experience with a custom NGS analysis and troubleshooting of NGS assay designs
• Strong understanding of the molecular and cellular biology associated with gene expression and sequencing.
• Strong experience with primer design, PCR technology, and molecular barcoding methods
• Proficiency in Python, R and Shiny, Linux shell scripting. Experience with C++ and Java is a plus
• Strong background in statistics and experience with standard RNAseq libraries.
• Direct experience with single cell transcriptomic analysis
• Excellent communication and organizational skills.
• Proficiency in scientific data presentation and visualization
• Flexibility and resourcefulness in working in a highly dynamic and demanding environment.

Our global team of more than 75,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen,Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit www.thermofisher.com.

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.