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Sr. Research Associate, Pharmaceutical Development
Company: Kezar Life Sciences
Location: South San Francisco, CA
Employment Type: Full Time
Date Posted: 02/24/2021
Expire Date: 04/24/2021
Job Categories: Biotechnology and Pharmaceutical
Job Description
Sr. Research Associate, Pharmaceutical Development
Kezar Life Sciences (NASDAQ: KZR), a clinical-stage biotechnology sciences company located in South San Francisco, is seeking a Sr. Research Associate, Pharmaceutical Development. The position reports to the Scientist, Pharmaceutical Development and will develop preclinical and clinical formulations, and the analytical methods to characterize them, in support of our small molecule immunology and oncology programs. The successful candidate will be part of a dynamic, interdisciplinary team requiring a high degree of creativity and initiative. This is an exciting time to help drive the development of novel therapies for unmet needs in multiple indications.

Kezar is focused on small molecule drug discovery and development to target immune-mediated diseases and cancer. Kezar’s lead product candidate, KZR-616, a selective inhibitor of the immunoproteasome, is being evaluated in Phase 2 clinical trials for the treatment of severe autoimmune diseases. KZR-261, Kezar’s first oncology candidate targeting the protein secretion pathway via the Sec61 translocon, is entering Phase 1 clinical trials in several oncology indications.

RESPONSIBILITIES
• Develop small molecule HPLC and other analytical methods
• Participate in small molecule preclinical and clinical formulation design and development
• Assist in analytical method transfers, drug product manufacturing technology transfers, and other CMO/CRO
oversight activities
• Prepare and characterize formulations for preclinical studies
• Keep an accurate and detailed electronic laboratory notebook
• Maintain and troubleshoot laboratory Instruments
• Additional responsibilities may be added as required

REQUIREMENTS

• Bachelor’s Degree in Chemistry, Pharmaceutical Sciences, or related field with minimum 2 years Pharmaceutical
industry. Master’s Degree in Chemistry, Pharmaceutical Sciences, or related field preferred
• Knowledge and understanding of small molecule analytical methods development and qualification/validation
• Good understanding of basic organic chemistry
• Expertise in HPLC and other small molecule analytical techniques
• Pre-formulation and formulation experience. Experience in Parenteral formulations is a plus
• Very strong problem-solving and troubleshooting skills
• Technical writing experience such as protocols, reports, and SOPs
• Ability to communicate complex scientific findings and recommendations in one-on-one discussions,
departmental meetings, and written reports
• Proficiency in preparing presentations using PowerPoint
• Ability to work in a fast paced, dynamic environment with multiple projects, priorities, and personalities
Contact Information
Website: https://apply.workable.com/kezar/j/...
Company Description:
Founded in 2015 and based in South San Francisco, Kezar (pronounced “keys are”) Life Sciences is combining courage, conviction and cutting-edge science to develop breakthrough treatments for immune-mediated and oncologic disorders – with the hope of helping people overcome their disease and live a better life. We are pioneering first-in-class, small molecule therapies that harness master regulators of cellular function to inhibit multiple drivers of disease via single, powerful targets. We are translating our innovative research in protein degradation (via immunoproteasome inhibition) and protein secretion (via the Sec61 translocon) to have a significant clinical impact in the most difficult-to-treat diseases.
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